Nasenmann:Es kann (wie alles andere auch) Allergien auslösen.
en.wikipedia.org/wiki/Tetramethyl_acetyloctahy
dronaphthalenes#SafetySafety
Iso E Super may cause allergic reactions detectable by patch tests in humans and chronic exposure to Iso E Super from perfumes may result in permanent hypersensitivity. In a study with female mice, Iso E Super was positive in the local lymph node assay (LLNA) and irritancy assay (IRR), but negative in the mouse ear swelling test (MEST).
No data were available regarding chemical disposition, metabolism, or toxicokinetics; acute, shortterm, subchronic, or chronic toxicity; synergistic or antagonistic activity; reproductive or teratological effects; carcinogenicity; genotoxicity; or immunotoxicity.
The International Fragrance Association (IFRA) has published safe use levels for Iso E Super in consumer products.
OTNE is not toxic and not a CMR substance.
OTNE is classified as a skin irritant (R38 EU DSD, H315 EU CLP) and is positive in the Local Lymph Node Assay (LLNA – OECD 429) and therefore classified as a skin sensitiser (R43 EU DSD, H317 EU CLP), though OTNE lacks any structural alerts for sensitisation in in-silico prediction models (DEREK) and is not identified as an allergen in in-vivo Human Repeated Patch Tests.
Several health related studies have been conducted on OTNE, and based on these studies, OTNE has been determined to be safe under the current conditions of use.
Given the sensitization classification of OTNE, and its use in fragrances, the International Fragrance Association (IFRA) has published safe use levels for OTNE in consumer products, which have been in effect since August 2009.
*OTNE ist eine andere Bezeichnung für Iso-E-Super
Okay, alles klar. Aber müssten dann nicht Parfums wie Molecule 01 einen Warnhinweis haben? Ich denke da an Lebensmittel, die Allergene enthalten, die müssen ja auch gesetzlich irgendwie markiert werden.